Associate Scientist, Automation

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences Engineering team and build automation capabilities that accelerate the development of our next-generation gene editing tools. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. This individual will play a key role in discovery and engineering efforts, advancing recombinase-based genome editing platforms and collaborating across diverse R D teams.

Key Responsibilities Accountabilities:

• Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows
• Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT)
• Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products
• Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens
• Coordinate DNA synthesis and reagent orders with external vendors
• Manage raw material, plasmid, and RNA inventories
• Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks
• Present findings clearly to other teams and contribute to scientific discussions and decision-making

Qualifications Skills:

• BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field
• Experience with automated liquid handling systems (e.g., Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting
• Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
• Hands-on molecular biology experience, including cloning and RNA production and purification
• Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling
• Experience with laboratory inventory management
• Track record of generating precise, reproducible data and performing rigorous quantitative analysis
• Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences
• Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects
• Strategic thinker who effectively plans and prioritizes to maximize scientific impact
• Collaborative mindset with a team-first attitude
• Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty

Pay Range: $105,000 - $120,000