Research Associate/Senior Research Associate - High Potent APIs (HPAPI)/Organic/Antibody Drug Conjugation (ADC)

High Potent APIs (HPAPI):

• Perform hands-on laboratory chemistry activities involving high-potency APIs / potent compounds.
• Execute chemical reactions, work-ups, purification and related laboratory processes.
• Handle HPAPIs in accordance with applicable safety, containment and handling procedures.
• Maintain accurate laboratory records, experimental data and documentation.
• Support process development, optimization and troubleshooting activities.
• Perform analytical sample preparation and coordinate with analytical teams as required.
• Follow established GMP, EHS and laboratory safety requirements.
• Support investigation and resolution of laboratory/process-related issues.
• Where required, support chemistry activities related to ADC and highly potent payloads.
• Work effectively with cross-functional teams including analytical and other chemistry groups.

Organic Chemist:

• Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance
• Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography
• Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations
• Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately

Peptide Chemist:

• Hands-on expertise in solid-phase and solution-phase peptide synthesis using automated synthesisers like Syro and Liberty CEM
• Strong experience in peptide purification, characterisation, and analytical techniques, including HPLC, LCMS, and MS
• Capable of independently handling medium- to large-scale peptide synthesis (1 g to 1 kg scale) with troubleshooting abilities
• Skilled in laboratory operations, equipment maintenance, SHE compliance, literature review, and accurate experimental documentation

Scaleup Chemist:

• Experience in process R&D, scale-up synthesis, and purification from gm to kg scale
• Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities
• Proficient in 1H NMR, HPLC, and LCMS interpretation
• Strong project execution and team collaboration skills

Antibody Drug Conjugation Chemist (ADC)

• Synthesis and purification of complex antibody drug conjugate (ADC) molecules
• Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs
• Synthesis of highly potent drug molecules – payloads
• Purification of complex and large molecules by flash column and HPLC
• Handling various type chemistry with different payloads
• Interpretation and characterisation of higher molecular weight compounds